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American scientists have developed a new method for the treatment of obesity

American scientists have developed a new method for the treatment of obesityThe American company Ortho-McNeil Pharmaceutical, Ink. found a very effective method for the treatment of obesity on the basis of topiramate that you want to consume in a daily dose of 25-400 mg This method provides a significant reduction in the rate of increase of the weight in a mammal by reducing the metabolic efficiency of food, in particular, with selective reducing the formation and accumulation of lipid in adipose tissue. Science has long known chemical compound (pictured right), which belongs to the structurally new antiepileptic compounds having a high anticonvulsant activity in animal experiments. One of these compounds - sulpham 2,3:4,5-bis-O-(1-methylethylidene)-b-O-fructopyranose known as topiramate, manifests, as has been shown in clinical studies on epilepsy human efficiency through additional remedial measures or monotherapy in the treatment of partial epileptic seizures and seizures of epileptic automatism, as well as secondary large seizures and is currently marketing trials in the UK, and Finland. The United States and Sweden in the treatment of partial epileptic seizures and seizures of epileptic automatism in the presence or in the absence of large secondary epileptic seizures, and the application for a permit their application currently being considered in various countries of the world. Studies 1994 it was known that the compounds of the above formula possess anticonvulsant activity in the traditional test for obtaining maximum convulsing under the action of electroshock in mice (MEAs). In subsequent studies it was shown that the compounds of this formula are highly effective in the MES test in rats. It was recently revealed that topiramate is effective in preventing the development of epileptic seizures in some models of epilepsy in rodents. Recent preclinical trials of topiramate revealed previously unknown pharmacological properties of this product, which suggests its potential effectiveness in the treatment of obesity. In particular, it was found that the compounds of this formula, where X represents O or CH2, and R1, R2, R3, R4 and R5 are applicable for the treatment of obesity. The activity of compounds of this formula in the treatment of obesity was first shown in several preclinical long-term (from three months to two years) tests. Topiramate caused a significant decrease in the rate of weight gain or body weight loss in rodents and dogs by oral administration in doses of 10 mg/kg Analysis of food consumption in these studies indicates that the effect of topiramate on body weight is associated rather with a decrease in metabolic efficiency than with reduced food consumption. In clinical studies, in which topiramate was administered to patients with epilepsy, loss of body weight was a statistically significant adverse effect. The most significant reduction in rate of weight gain in a mammal by reducing the metabolic efficiency of food, in particular, with selective reducing the formation and accumulation of lipid in adipose tissue, has achieved Shank Richard P. from American company Ortho-McNeil Pharmaceutical, Ink.. His research showed that for the treatment of obesity in adults the connection of this formula can be entered in a daily dosage of from about 50 to 200 mg, in two separate doses. Standard dose contains from about 25 to 100 mg of active ingredient. In the manufacture of the compositions in oral dosage forms based on this compound may be any of the usual pharmaceutical environment. The effects of compounds on body weight, is primarily the result of reduced metabolic efficiency and reduce food intake, which, in turn, leads to a reduction of fatty tissue in the body. Tests were conducted on laboratory animals, which were injected topiramate daily for 28 days. Subsequent analysis showed that even at 15 mg / kg reduced in rats that were injected topiramate was associated with a selective decrease in the formation and accumulation of lipid in adipose tissue. SciTecLibrary.ru.



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